Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological objectives and you may pharmacology out-of curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin ‘s the significant part of this new red-colored color of turmeric, an Indian spruce that’s taken from the newest rhizome of the exotic plant Curcuma longa, and therefore is one of the Zingiberaceae relatives. Within section, we talk about the pharmacological things regarding curcumin and you can mention the unit bases for those affairs. I after that opinion the new proven and possible scientific spends regarding curcumin. Curcumin is well known typically since the a therapeutic representative, however, their procedure away from action try detail by detail. The new pharmacological results of curcumin appear to be caused by good synergism off channels away from weakened biochemical interactions with several biological targets in the interrelated signaling routes. This type of plans philippines Г¦gteskabsturnГ© were nutrients such as for example cyclooxygenase, lipoxygenase and you can protein kinases, and you may transcription situations particularly NF-?B, STAT and you may Nrf2. Modulation of these molecules influences downstream affectors that produce the fresh antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial points of curcumin. These types of consequences was in fact checked into the health-related samples out-of curcumin getting discomfort and you can inflammatory illness, cancer tumors, Alzheimer problem, cardio infection, and you can diabetic issues. The brand new examples purchased adjustable amounts out of curcuminwith additional wavelengths and you may years, into general completion you to definitely large doses out of curcumin on quantity of g have to obtain therapeutic consequences. Find out more
Curcumin: Synthesis, Emerging Character for the Problems Management and you will Wellness Implications
Book Part Examples of bush-derived pharmaceuticals having become the appeal out of continuous and you will exponential lookup and you may innovation attract features, at this point, started slightly scarce. Once several years, the very last 20 years were characterized by a beneficial 100-fold escalation in just how many scientific posts published a year that is actually off benefits towards the use of curcumin into the biomedicine. Read more
Structure, synthesis and you may biological situations out of curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has some prospective pharmacological outcomes that can provides healing apps in lot of problem says, once the discussed in more detail in the earlier section. But not, the potential scientific effectiveness out-of curcumin is limited by the physicochemical characteristics regarding poor liquids solubility and you will instability, and therefore result in reduced bioavailability. Prodrugs from curcumin promote a means to improve of one’s biopharmaceutical and you will pharmacokinetic properties, and may even make it exploitation of pharmacological aftereffects of curcumin. Contained in this chapter, i first review the brand new physicochemical and you may pharmacokinetics off curcumin. We then establish the style of curcumin prodrugs with enhanced h2o solubility and you can enhanced chemical substances balances which are translated back again to free curcumin abreast of bioactivation within the vivo. We high light latest achievement in this region, that have a concentrate on the structure, synthesis and you may review away from prodrugs considering promoieties along with amino acids, fatty acids, nucleic acids, dicarboxylic acids, and polymeric content such hyaluronic acidic and polyethylene glycol. It part provides the reason for optimisation of one’s physicochemical and you will biopharmaceutical services in addition to biological activities out-of curcumin prodrugs, towards the purpose using of them curcumin types when you look at the systematic apps. Find out more